A New Age for Recombinant Human Thyroid-Stimulating Hormone?

Recombinant human thyroid-stimulating hormone in radioiodine thyroid remnant ablation.

BACKGROUND To prevent the unwarranted effects of post-thyroidectomy hypothyroidism prior to radiodine (RAI) ablation, patients with well-differentiated thyroid cancer can currently undergo this treatment while in a euthyroid state. This is achieved with the use of recombinant human thyroid-stimulating hormone (rhTSH) injections prior to the ablation. OBJECTIVES To demonstrate the efficacy of ...

Coming of age: recombinant human thyroid-stimulating hormone as a preparation for (131)i therapy in thyroid cancer.

Recombinant human thyroid-stimulating hormone (rhTSH) was approved for diagnostic testing by the U.S. Food and Drug Administration in November 1998. It has subsequently been approved in Europe and Australia and is available in many other countries on a restricted basis. Approval was based on its ability to stimulate the uptake of radioiodine into thyroid remnants and metastases of thyroid cance...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone

Recombinant human thyroid stimulating hormone in 2008: focus on thyroid cancer management

Radioiodine (RAI) ablation following thyroidectomy is standard of care treatment for patients with intermediate or high risk differentiated thyroid cancer. Traditionally, this has been achieved by forgoing thyroid hormone replacement postoperatively, allowing endogenous thyroid stimulating hormone (TSH) levels to rise. This rise in TSH provides the stimulus for RAI uptake by the thyroid remnant...

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.

Human thyrotropin (TSH), luteotropin (LH), follitropin (FSH), and chorionic gonadotropin are members of the heterodimeric glycoprotein hormone family. The common alpha subunit forms noncovalent heterodimers with different beta subunits. Two novel human glycoprotein hormonelike genes, alpha2 (A2) and beta5 (B5), recently have been identified. Using a yeast two-hybrid assay, the two subunits were...